It will matter little in the grand scheme of this season, but Liverpool's second defeat of their Premier League campaign came with warning signs for what will surely be the title defense of next season.

Southampton became the first team to be relegated from the Premier League this season after a 3-1 defeat to Tottenham on Sunday. With just 10 points from 31 games, last-placed Southampton cannot finish above Wolverhampton Wanderers in 17th.

Fulham's Alex Iwobi, right, challenges for the ball with Liverpool's Mohamed Salah during the English Premier League soccer match between Fulham and Liverpool, at Craven Cottage, London, Sunday, April 6,