Looking back at a nightmarish history for the New Orleans Saints against the San Francisco 49ers, one of their oldest rivals:

The San Francisco 49ers earned a road win in Week 1, and they'll stay on the road for Week 2. Here's how to tell if the game will be on TV near you.

Just days before their season opener, Jennings, who dealt with a calf injury during the preseason, and the 49ers agreed to rework his contract, adding $3 million in play-time incentives that would increase his earnings to as much as $10.5 million.

Purdy’s game-winning drive was the kind of performance you expect from a quarterback making more than a quarter of a billion dollars — franchise money. He purged the bad play that preceded it and made big-time plays when big-time plays were needed. And this season, it looks like they are going to be needed quite often.

Week 1 of the 2025 NFL season was pretty good to the NFC West. Well, it was good to all but one team. The division went 3-1, and that one loss was inevitable because there was a divisional matchup in Week 1. The only team to lose was the Seattle Seahawks.

The 49ers overhauled their defensive front this spring, including drafting Mykel Williams in Round 1. The Seahawks did the same on offense.

The 49ers won their NFL season opener by overcoming blunders and rallying 17-13 over the host Seattle Seahawks.

On the field for all 52 defensive snaps, Sigle was far and away the better safety on Sunday, making impact plays all over the field. Saleh blitzed him, used him as a single-high safety, a robber, and a hook and flat defender. He was excellent against the run and a step ahead in the pass game.

Other questions this week include why the 49ers said goodbye to Jordan Mason and how Nick Martin will crawl into the game-day lineup.

In his first public comments since he was diagnosed with cancer, Bay Area media legend and current San Francisco 49ers play-by-play broadcaster Greg Papa revealed the extent of his battle and how serious his diagnosis is.