Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five drives and seven of eight possessions overall. Brock Purdy threw for 295 yards and three touchdowns, while Murfreesboro's Jauan Jennings caught two touchdown passes.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

It wasn’t a pretty first half, but the San Francisco 49ers bounced back to blow out the Cleveland Browns in Week 13.

McCaffrey was not among the 49ers (9-4) listed as inactive Sunday before their game against the Tennessee Titans (2-11) at Levi’s Stadium. Listed as inactive for the 49ers were wide receiver Jordan Watkins,

The 49ers are 12.5-point favorites, per the latest Titans vs. 49ers odds, and the over/under for total points scored is 44.5 at DraftKings. The 49ers are -901 money line favorites (risk $901 to win $100),

San Francisco 49ers wide receiver Ricky Pearsall is dealing with multiple injury concerns following Week 15’s win vs. the Titans.

They could certainly get it if they beat the Patriots at Gillette Stadium and put an end to their 10-game winning streak. The Bills are