Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a ...
Gene therapy mediated by recombinant adeno-associated virus (AAV) vectors is a promising treatment for systemic monogenic diseases. However, vector immunogenicity represents a major limitation to gene ...
Fig. 1: Serum concentrations of AAV-expressed HIV IgG biologics in groups 1–3 and outcome of oral SHIV-AD8 EO challenges. The alternative text for this image may have been generated using AI. To ...
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