During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and viruses from self-antigens that are expressed by cells of the body. If not, the ...

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.

Chronic lymphocytic leukemia (CLL) is a heterogeneous B cell malignancy characterized by the accumulation of functionally incompetent B lymphocytes. Despite the availability of highly effective ...

Pathogenesis of endometriosis is still unclear and a role of both innate and adaptive immune system has been postulated. Some recent findings have revealed an increased risk to have concomitant ...

Studying mice, researchers have discovered that roseolovirus can trigger autoimmunity in a previously unknown way: by disrupting the process by which immune cells learn to avoid targeting their own ...

Our genome contains vast networks that regulate the activity of protein-coding genes. Variations in this regulatory DNA (which does not encode proteins) may affect both when and how much of a given ...

A study provides evidence that the prevalence of autoimmunity -- when the immune system goes awry and attacks the body itself -- has increased in the United States in recent years. A study published ...

Autoimmunity When our bodies are exposed to a virus — or any infection — it recognizes proteins and other molecules on the invading virus as “not us.” Scientists refer to this as an antigen. We then ...

Melanocyte melanin synthesis creates constitutive ROS vulnerability, and impaired Nrf2-mediated antioxidant responses enable ...

The immune system defends the body against a wide range of internal and external threats. However, this versatility becomes an issue when immune mechanisms target host cells instead—a phenomenon ...

Please provide your email address to receive an email when new articles are posted on . van Trotsenburg and Mooij are pediatric endocrinologists at Emma Children’s Hospital, Amsterdam University ...

Summary of the research: This study revealed that T cells can discriminate between self- and neoself- antigens, and that neoself-reactive T cells are involved in causing autoimmune diseases. Osaka, ...