The patch clamp is a laboratory technique for studying currents in living cells. It is usually carried out by applying a voltage across the cell membrane and measuring the resulting current. An ...

Historically, researchers impaled giant squid, snail, and frog axons with electrodes to study nerve function by measuring ion channels. Today, electrophysiologists have enhanced their ability to ...

The study of electrophysiology began in the 18 th century with Luigi Aloisio Galvani’s pioneering experimental discovery. The legs of a dead frog could be induced to twitch when a small electric shock ...

According to proteomics analyses, more than 70 different ion channels and transporters are harbored in membranes of intracellular compartments such as endosomes and lysosomes. Malfunctioning of these ...