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LpxC inhibitors target a zinc-dependent deacetylase that catalyses the first committed step in lipid A biosynthesis, an essential process for the viability of Gram-negative bacteria. As lipid A forms ...

The proportion of extensively drug-resistant (XDR) Shigella isolates in the United States increased from 2011–2015 to 2023, according to research published in the April 9 issue of the U.S. Centers for ...

The Tol-Pal complex maintains bacterial outer membrane (OM) stability by regulating lipid homeostasis. (Left) In Gram-negative bacteria, the OM acts as a protective barrier, blocking entry of harmful ...

A tool for better antibiotic stewardship did not improve clinical outcomes in hospitalized patients with gram-negative bacterial bloodstream infections, according to the international FAST trial. The ...

Scientists from Cornell University, University of California, San Francisco (UCSF), and elsewhere have found that a surplus of membrane proteins may help bacteria survive antibiotic exposure. These ...

Researchers have determined a protein’s essential role in bacterial envelope structure and function, which could inspire a search for better antibiotics. Researchers at Johns Hopkins University (MD, ...

Rapid antimicrobial susceptibility testing for gram-negative blood infections shows no improvement in clinical outcomes ...

A new study published in the Journal of the American Medical Association revealed that rapid blood culture antimicrobial ...