Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and the middle. Is everything packed? What time should we leave? Will there be ...

A new study finds that when p53, one of the most important cancer-protecting genes, stops working, cells produce too much RNA ...

Sarah J. Aitken is at the Center of Molecular and Cellular Oncology, Yale Cancer Center, New Haven, Connecticut 06511, USA, and in the Department of Pathology, Yale School of Medicine, New Haven. Read ...

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...