The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

IgG subclasses differ in their effector functions in a variety of in vitro assays. To assess the effect of antibody subclass differences on in vivo protective efficacy against herpes simplex virus ...

IgG was the only class of antibodies that were actively transported from mother to offspring for a long time, and this resulted in short-term passive immunity. The specific IgG transport was realized ...

A Japanese research team has uncovered how sugar chains (glycans) modifications dynamically regulate the structure and function of human immunoglobulin G (IgG) antibodies. By integrating nuclear ...

From this core mechanism Fc engineering has evolved over time into the "engine" of therapeutic antibody development. It ...

Daniel R. Lucey, Stephen A. McGuire, Mario Clerici, Kevin Hall, Jean Benton, Clifford A. Butzin, William W. Ward, Gene Shearer, R. Neal Boswell and Craig W. Hendrix β₂-microglobulin levels were ...