The American Society of Regional Anesthesia and Pain Medicine has published a practice advisory on local anesthetic systemic toxicity (LAST) called “Guidelines for the Management of Severe Local ...

Over the last decade, poisonings and deaths linked to the use of local anesthetics have decreased. Even so, poisonings from one commonly used anesthetic, lidocaine, have increased in the United States ...

A new study published in the Feb. 2012 issue of Anesthesiology found that the type of lipid emulsion used to reverse toxicity of local anesthetics may change the effectiveness of the reversal, ...

Lipid emulsion therapy has emerged over the past two decades as a life-saving intervention for local anaesthetic systemic toxicity (LAST). Intravenous administration of a triglyceride-rich emulsion ...

A liposomal formulation of a local anesthetic shows promise for long-lasting pain relief with minimal toxicity, reports a research group led by Daniel S. Kohane of Harvard Medical School (Proc. Natl.

Local anesthetics are widely used for pain control, but carry an inherent risk of systemic toxicity, referred to as LAST, prompting multiple professional societies to issue recommendations in 2010 to ...

Inspired by the natural bonding between a class of potent local anesthetics called site-1 sodium channel blockers (S1SCBs) and peptide sequences on the sodium channel in the nerve cell membrane, ...

Please provide your email address to receive an email when new articles are posted on . Use of tumescent anesthesia allows for equal anesthetic distribution across large areas while decreasing the ...

In the early 15th century C.E., a doctor in China was entombed with surgical instruments. Recent analysis of residues left on ...