Roughly one-half of all cases of Lynch syndrome with an identified gene mutation are associated with the MLH1 gene. (1) In addition to MLH1, scientists have identified four other gene alterations that ...

Suicide gene therapy with herpes simplex virus thymidine kinase (HSV-TK) and ganciclovir (GCV) is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase.

Lynch syndrome is the most common cause of hereditary colon cancer. It is a genetic condition that puts people at an increased risk for cancer. People with Lynch syndrome typically get diagnosed with ...

What does an MLH1 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the same mutation. Your distant family ...

Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong ...

Lynch syndrome is an inherited condition that increases the risk of developing some cancers, including colorectal cancer. A large proportion of people in the UK with Lynch syndrome will be unaware ...