Methotrexate monotherapy demonstrated statistically significant and clinically relevant improvement of symptoms and physical function compared with placebo at 12 to 52 weeks. Multiple adverse effects ...

Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, ...

Subcutaneous tocilizumab, either as monotherapy or in combination with methotrexate, demonstrated greater efficacy than methotrexate alone and was well tolerated in patients with active rheumatoid ...

A network meta-analysis confirmed the efficacy of methotrexate for patients with rheumatoid arthritis (RA) and validated it as the primary reference conventional synthetic disease-modifying ...

Biosimilar DMARDs offer cost-effective and improved outcomes over leflunomide for RA patients unresponsive to methotrexate. The study used a Markov model with data from 25,099 RA patients to simulate ...

Methotrexate may cause modest weight gain, especially if you are underweight when you start treatment. If you gain weight on methotrexate, eating healthy and exercising can help you manage it. Some ...

Patients with early rheumatoid arthritis (RA) who delayed starting methotrexate for a month to receive the 13-valent pneumococcal conjugate vaccine (PCV13) did not have worse disease control, more ...

People with RA who stop taking methotrexate treatment for just two weeks after they have a seasonal flu shot can improve the vaccine's efficacy without increasing RA disease activity, according to new ...

New research suggests that tissue-resident macrophages occupy a fibrin-rich niche and actively remodel the synovial lining in rheumatoid arthritis, providing insights into the mechanisms underlying ...

Mississippi awarded more than $104 million in federal rural health grants across 167 projects. Where the money goes and why rural access matters. Community paramedics in rural Virginia visit patients ...