Studies in animal models by UF Scripps Biomedical Research scientists have identified a protein that could shed light on how people develop tolerance to pain-relieving drugs over time, a problem that ...

New research has identified an alternative signaling pathway in the brain of mice that relieves pain, even in animals that have developed tolerance to opioids. The study also showed that pain relief ...

The opioid epidemic in the United States has exacted an incalculable toll on individuals and communities, creating an urgent need for alternative painkillers. The search for non-opioid treatments is ...

A newly discovered brain pathway in mice may contribute to the development of opioid tolerance, suggesting that future therapies targeting this pathway could prevent opioid addiction and overdose.

UF Scripps Biomedical Research scientists have a discovered a key gene that is shedding light on how people develop tolerance to pain-relievers over time, a problem that raises risk of addiction and ...

Duke University researchers have devised a promising, potent pain reliever — seemingly without the harmful side effects and addictive highs of opioids. While opioids interact with numerous cellular ...

The Klein lab is located in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. The current focus of Dr. Klein's research revolves around the neural mechanisms of pain ...

Immunofluorescence staining of a tumor section from a patient with oral cancer. Human oral cancer cells (white) express abundant EGFR (red) within the tumor and in the adjacent peripheral nerve (green ...

AURORA, Colo. (August 28, 2025) – A new study from University of Colorado Anschutz and Denver Health researchers, published today in JAMA Network Open, introduces a more individualized approach to ...

A recent study explodes the myth that the risk of addiction to prescription opioids exists only among patients abusing their opioids. Until recently, the National Survey on Drug Use and Health (NSDUH) ...

Against expert advice, people are using new and unpredictable synthetic drugs to experiment on themselves in hopes of ...