Two early games against Rams, return to MetLife Stadium and latest bye in franchise history as San Francisco chases return to Super Bowl.

I njuries are already biting the San Francisco 49ers after two of their top players were dinged up last week in the season-opening win over the Seattle Seahawks, yet the Niners are still 4.5-point favorites in Week 2.

Arizona Cardinals The Cardinals traveled to Caesar’s Superdome to face the New Orleans Saints and walked away with a 20-13 win. Kyler Murray was steady in the passing game; finishing 21-29 for 163 yards and 2 touchdowns,

You can listen to Seahawks vs. 49ers live on SiriusXM. Coverage will be available on channel 226 (Seahawks) and 381 (49ers). SiriusXM NFL Radio is available to listeners on national satellite channel 88.

The Los Angeles Rams were able to come back from an early deficit to beat the Houston Texans 14-9. Matthew Stafford also became the tenth quarterback in NFL

Former 49ers cornerback Richard Sherman believes San Francisco needs to move on from struggling kicker Jake Moody.

Discover our expert Week 2 fantasy football D/ST rankings, with the Broncos, Rams, and 49ers among the top defenses to start in your lineup.

Learn which TV channel or how to live stream the NFL Week 1 Seattle Seahawks and San Francisco 49ers game, Sunday, Sept. 7.