Synaptic plasticity—the ability of neural connections to adapt in strength and efficacy—is fundamental to learning, memory and emotional regulation. At the molecular level, long-term potentiation (LTP ...

Major depressive disorder (MDD) is generally associated with synaptic damage in specific brain regions. However, the molecular mechanisms underlying the pathogenesis of MDD remain largely unknown. In ...

How do we learn something new? How do tasks at a new job, lyrics to the latest hit song or directions to a friend's house become encoded in our brains? The broad answer is that our brains undergo ...

Recent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism ...

Scripps Research postdoctoral researcher Kaushik Chanda explores the mechanisms by which non-coding transcripts modulate neuronal function and structural integrity during learning and memory loss.

An early burst of GPR3 activity helps convert short-term cellular signals into long-term programs that support neuron growth, ...