Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications ...

Researchers analyzed the thermodynamics of doxepin binding to the histamine H1 receptor. The findings highlight the ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Since statins first came to market in the late 1980s, muscle aches, weakness, and fatigue have driven many patients to ...

Understanding the thermodynamic basis of ligand recognition by G-protein-coupled receptors (GPCRs), especially in terms of ...