Cycloaddition reactions represent a cornerstone of synthetic organic chemistry, facilitating the formation of cyclic structures through concerted pericyclic processes. Traditionally explained via ...

Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure. Automated reaction path search method predicts accurate ...

In chemical reactions, molecules transform from reactants into reaction products through a critical geometry called a transition state that lasts less than one millionth of one millionth of a second.

Pericyclic reactions, which involve concerted electron movement and a cyclic transition state, have long been a part of the synthetic chemist’s tool box. But finding enzymes that catalyze such ...

Reductive elimination reactions, in which a transition metal catalyzes new bond formation between two molecules, are one of organic chemists’ most powerful tools. For example, one flavor of these ...

Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure. Researchers at the Institute for Chemical Reaction Design and ...