San Francisco 49ers running back Christian McCaffrey reflects on getting a win vs. his former team, the Carolina Panthers.

San Francisco 49ers running back Christian McCaffrey had a memorable performance against his former team, Carolina Panthers, ...

San Francisco 49ers head coach Kyle Shanahan gives remarks following the Week 12 matchup vs. the Carolina Panthers.

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

Watch the top runs from Week 12 of the 2025 NFL season. Highlights from the Week 12 matchup between the Carolina Panthers and ...

Highlights from the Week 12 matchup between the Carolina Panthers and the San Francisco 49ers during the 2025 NFL season.

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

San Francisco 49ers wide receiver Jauan Jennings struck Carolina Panthers safety Tre'von Moehrig twice shortly after the ...

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome ...

San Francisco 49ers kicker Matt Gay connects on a 29-yard field goal to extend the 49ers lead over the Carolina Panthers to ...

Carolina Panthers cornerback Mike Jackson leaps up and snatches an incredible interception in the end zone off San Francisco ...

San Francisco 49ers running Christian McCaffrey puts the ball on the ground but offensive tackle Colton McKivitz is somehow ...