The Tennessee Titans will take on the Kansas City Chiefs in Week 16 action. Here is one player who would give the Titans a boost.

The Tennessee Titans host the Kansas City Chiefs this weekend. The Titans are dealing with significant injury issues on the offensive line and defense.

USA Today's NFL experts make their picks for a Week 16 showdown between the Tennessee Titans and Kansas City Chiefs

The Tennessee Titans (2–12) are back at Nissan Stadium this week, set to host the Kansas City Chiefs (6–8) in a Sunday noon kickoff on Dec. 21. It’s a homecomin

The Tennessee Titans have major injury issues at safety and linebacker, creating a big opportunity for star Chiefs tight end Travis Kelce.

Find single game tickets to the Kansas City Chiefs vs. Tennessee Titans NFL Week 16 matchup on Sunday, Dec. 21, 2025 at Nissan Stadium.

The Chiefs-Titans game will be on CBS (KCTV 5 in Kansas City). In Wichita, it’s on KWCH (Channel 12). The game will also be broadcast on radio via KFNZ (96.5 FM) in the KC area and KNSS (98.7 FM) in the Wichita area. Despite losing Mahomes, the Chiefs are a 3 1/2-point favorite with the over/under set at 37 1/2.

Pregame analysis and predictions of the Kansas City Chiefs vs. Tennessee Titans NFL game to be played on December 21, 2025 on ESPN.