Injuries to the team's linebacking corps have contributed to the run defense's woes. Star LB Matt Milano has missed three games because of a nagging pectoral injury. LB Terrel Bernard — who leads the team in tackles (30 in six games) — injured his ankle against Atlanta.

Legendary NFL cornerback Ty Law made one bold comparison between Patriots quarterback Drake Maye and Tom Brady.

New England opens with a bootleg pass to Stefon Diggs (who else?), who promptly finds open grass for a first down. But then the Bills defense counters immediately, swallowing up Rhamondre Stevenson's first carry and then sacking Maye on third-and-long. Already we can see this matchup will be a test for the Patriots' offensive front.

It's the New England Patriots vs Buffalo Bills this Sunday at Highmark Stadium in an AFC East thriller. Live coverage begins at 7 PM ET on NBC and Peacock.

Here's the uniform combs for the Bills and Patriots for their Sunday clash at Highmark Stadium:

NFL Week 5 odds, picks, predictions, TV channel, streaming information for Sunday Night Football game between New England Patriots and Buffalo Bills.

Get the latest odds, predictions, picks, and analysis ahead of kickoff between the New England Patriots and New Orleans Saints

The New England Patriots and Buffalo Bills will face off in Orchard Park, New York. Here are the best prop bets for the Sunday Night Football matchup.

The Buffalo Bills have begun their preparation for a Week 5 matchup with the New England Patriots, a meeting that will either give the Bills a stranglehold on t

The Bills (4-1) were beaten for the first time this season by the New England Patriots (3-2) on "Sunday Night Football" in Week 5 in a 23-20 final. Both teams played a messy game at times. It was more often the Bills playing poorly with several different types of miscues on both sides of the ball.