Of course, Wyle is no stranger to garnering awards buzz, having earned 5 noms for Outstanding Supporting Actor in a Drama for his excellent work as up-and-coming surgeon Dr. John

In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"

Wyle's nod marks his first Emmy nomination in 26 years and his first ever in the category. But the actor is certainly no stranger to grabbing the attention of Emmy voters; this is his sixth Emmy nomination — and his sixth time turning voters' heads while wearing scrubs.