Although no one won the $266 million Powerball jackpot in the latest drawing on Wednesday, July 16, many players in Ohio took home a bit more cash. The winning numbers for Powerball on July 16 were 4, 21, 43, 48 and 49. The Powerball was 22 and the Power Play was 2x.

CLEVELAND, Ohio — The winning numbers are in for the Wednesday, July 16, 2025, Powerball jackpot, with the jackpot an estimated $264 million. The numbers are 4-21-43-48-49 Powerball 22 Power Play 2x. The Classic Lotto numbers are 2-3-14-31-34-49 Kicker 789374. The Saturday, July 19 jackpot is $5.4 million.