A major body organ for blood purification are kidneys, which eliminate toxins through urine. Kidneys control blood pressure levels and red blood cell production and balance the body’s minerals and ...
(A) Relative urinary cystine concentration of Slc3a1 KO and WT mice from both sexes. (B) Typical hexagonal cystine crystals from the urine of Slc3a1 KO and WT mice. Scale bar,100 μm. (C) Bladder ...
Pharmacological inhibition of megalin (also known as LRP2 [low-density lipoprotein receptor-related protein-2]) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in ...
aProximate TM is an advanced in vitro model of kidney proximal tubule cells (PTCs) that closely mimics physiological conditions. Derived from fresh human kidney tissue, aProximate TM PTCs are cultured ...
Preclinical data shows use of megalin receptors for intracellular delivery of a ligand-siRNA conjugate to silence production of target mRNA in the kidney Megalin-binding genetic medicines are ...
A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before. This model exhibits ...
Kyoto, Japan -- Developing advanced drug screening tools is crucial for the advancement of personalized medicine and the creation of more effective treatments. One organ receiving particular attention ...
The kidneys contain millions of microscopic blood vessels known as peritubular capillaries. These vessels recapture helpful nutrients like glucose and minerals and return them to your bloodstream for ...
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