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Mariners Make Major Announcement on Ace Pitcher Before Astros Series first appeared on Athlon Sports on May 22, 2025

The Houston Astros open a four-game series at Daikin Park with Seattle, which leads the AL West. Lance McCullers Jr. (0-1, 7.88 ERA) makes his third start for Houston against Seattle's George Kirby, who just activated from the injured list after a shoulder injury.

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As ABC’s Game of the Week, a matchup between the Houston Astros and San Francisco Giants is broadcasted on TV with the Astrodome making its first appearance. Viewers were treated to a massive Willie Mays home run to help the Giants beat Houston 10-1.

While waiting for word on Ronel Blanco's elbow, the Houston Astros' depleted rotation will have to adjust yet again, with all hands essentially on deck.

Pregame analysis and predictions of the Seattle Mariners vs. Houston Astros MLB game to be played on May 22, 2025 on ESPN.

MLB player prop bets and odds for Isaac Edgardo Paredes on Thursday, May 22, 2025, as the Houston Astros take on the Seattle Mariners.

Preview the May 22 matchup between the Seattle Mariners and Houston Astros with odds over/under, game spread, betting lines and more.

In the worst way, the Tampa Bay Rays needed to find a way to put together a couple of wins at George M. Steinbrenner Field. They did so, finishing off a series victory on Wednesday over the Houston Astros with an 8-4 win.