ebm.bmj

BMJ Evidence-Based Medicine

BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and ...
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Catalogue of bias: observer bias

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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances

Objectives Alteplase is commonly recommended for acute ischaemic stroke within 4.5 hours after stroke onset. The Third European Cooperative Acute Stroke Study (ECASS III) is the only trial reporting ...
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Online First

Correspondence on ‘Less is more for patients, practitioners, public and planet: a taxonomy for the harms of too much medicine’ ...
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Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group (RRMG). Rapid reviews (RRs) use modified systematic review (SR) methods to accelerate the review ...
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The effect of publication bias magnitude and direction on the certainty in evidence

Correspondence to Dr Mohammad Hassan Murad, Evidence-based Practice Center, Mayo Clinic, Rochester, MN 55905, USA; murad.mohammad{at}mayo.edu When decision makers make a recommendation based on ...
ebm.bmj

Rapid reviews methods series: Guidance on literature search

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RR) use modified systematic review methods to accelerate the review process ...
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Efficacy of smartphone apps used alone or with traditional interventions for smoking cessation: a systematic review and meta-analysis

Objectives To assess the efficacy of smartphone apps for smoking cessation (SC) used alone or combined with traditional interventions, and to determine whether apps based on psychological-behavioural ...
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Evaluating data extraction error by a large language model from randomised controlled trials: a large-scale empirical study

Objective To examine the potential errors of a general large language model (LLM) (ie, Claude 3.5 Sonnet) on data extraction from randomised controlled trials (RCTs). Design and setting An empirical ...
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Advancing shared decision-making towards social justice: insights into an intersectional and decolonial approach from a Brazil–Canada partnership

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Uncovering seeding trials: examining non-scientific purposes in clinical trials

Seeding trials —clinical studies designed primarily for marketing rather than scientific advancement—pose underappreciated risks to research integrity and patient safety. Sukhun Kang and colleagues ...
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FDA approval of benzgalantamine exposes flaws in the 505(b)(2) pathway for innovations on existing drugs

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