Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's ...

Leucine-rich repeat kinase 2 encodes a large, complex protein containing a kinase, a GTPase, and multiple protein-protein interaction domains. The interplay of its enzymatic kinase and signaling ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

Massage might help your brain flow regain its mojo. On June 4 in Nature, researchers led by Gou Young Koh at the Institute for Basic Science in Daejeon, South Korea, mapped the labyrinth of lymphatics ...

Glymphatic clearance, which relies on a network of astrocytic endfeet arranged along vessels of the cerebrovasculature, has been implicated in AD, though it is not without controversy. Perivascular ...

To find out, Parhizkar gave lemborexant to P301S/E4 mice, which express human mutant tau along with human ApoE4, a risk factor for AD (Apr 2017 conference news). In this model, tau tangles begin to ...

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s. Clinicians often use the mnemonic TRAP to recall its four key motor symptoms: tremor, rigidity, ...

What’s more, the annexin shrank these neurites, as seen by a reduction in the amount of LAMP1, a lysosomal protein that packs into these membrane swellings. The size or number of amyloid plaques ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...

Monocyte-derived microglia arise from hematopoietic stem cells, which divide throughout a mammal’s lifetime to generate monocytes. Over time, these stem cells accrue mutations, for example in DNM3TA, ...

Replacing rogue microglia with healthy ones can ameliorate, in a mouse model, a childhood neurodegenerative disease called Globoid cell leukodystrophy (GLD), aka Krabbe disease. The approach even ...