Ubiquitination requires three types of enzyme: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, known as E1s, E2s, and E3s, respectively.

Jun 28, 2025 · Ubiquitin is a small regulatory protein present in virtually all tissues of eukaryotic organisms, from yeast to humans. Discovered in 1975, its name reflects its ubiquitous nature …

The ubiquitination process relies on a sophisticated enzymatic system, ubiquitin domains, and ubiquitin receptors, which collectively impart versatility to the ubiquitination pathway. The …

Ubiquitin is attached to proteins by a cascade of enzymes comprising ubiquitin activating enzyme (E1), ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).

Jan 14, 2021 · Ubiquitin modifications control a plethora of vital cellular processes through proteolytic and nonproteolytic mechanisms, including proteasomal degradation and …

Aug 23, 2018 · Ubiquitin is a small protein that is found in almost all cellular tissues in humans and other eukaryotic organisms, which helps to regulate the processes of other proteins in the …

Apr 7, 2025 · Ubiquitin is a post-translational modifier of other proteins and can be conjugated to a protein as a single ubiquitin (monoubiquitination) or as a multiple ubiquitin (polyubiquitination).