p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response …

A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in the p53 gene may cause cancer …

Dec 15, 2025 · Abstract. Mutations in p53 are among the most common genetic abnormalities in cancer, and the loss of its normal function is a critical factor in cancer progression. In addition …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

Dec 19, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the …

Jun 15, 2025 · At the heart of this defense is a protein known as p53, often called the “guardian of the genome.” This protein is a component of a pathway that responds to cellular stress, …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

Jan 1, 2025 · We propose a model for how DNA binding by p53 is regulated by its disordered regions. Defects in the tumor suppressor protein p53 are found in the majority of cancers.

The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but …